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- Prevention Works
During the last fifty years or so, disease control in the pork industry has evolved mainly relying on antimicrobials, vaccines, elimination (depopulation, repopulation, eradication, modified early weaning), and/or regional control depending on the diseases of concern and resources available. Looking forward, it is clear that antimicrobial usage, under increasing scrutiny for both metaphylactic and therapeutic uses will decline, whereas the use of vaccines will likely rise.
John Harding
Professor, Swine Production Medicine, Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan
WORK EXPERIENCE
2012-2015: Professor, Department of Large Animal Clinical Sciences
2004-2012: Associate Professor, Department of Large Animal Clinical Sciences
1997-2004: President, Harding Swine Veterinary Service Prof. Corp. and Manager Swine Production Services, Big Sky Farms, Humboldt, SK
1991-2004: Consulting Veterinarian, National Pig Development Ltd. Canada/Genex Swine Group
1988-1997: Veterinarian, Animal Management Services, Humboldt, SK
ACADEMIC TRAINING AND BACKGROUND
Diplomate, American Board of Veterinary Practitioners, Swine Health Management, 2008
Master of Science, University of Minnesota, 1997
Doctor of Veterinary Medicine, Ontario Veterinary College, University of Guelph, 1988
SELECTED ACCOMPLISHMENTS AND HONOURS
Pfizer Animal Health Award for Research Excellence, 2010
Pfizer Carl J. Norden Distinguished Teaching Award, 2009
Allen D. Leman Science in Practice Award, Pfizer Animal Health, 1999
SELECTED PEER-REVIEWED PUBLICATIONS (selected from total of 60 total)
Research theme: Reproductive PRRS
Wilkinson, J. M., Ladinig, A., Bao, H., Stothard, P., Lunney, J. K., Harding, J.C.S., Plastow, G.S. 2016. Differences in Whole Blood Gene Expression Associated With Infection Time-course and Extent of Fetal Mortality in a Reproductive Model of type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection. Plos One. Accepted Mar 1, 2016 MS# PONE-D-16-04940R1
Yang, T., Wilkinson, J., Wang, W., Ladinig, A., Harding, J., Plastow, G. 2016. A genome-wide association study of fetal response to Porcine Reproductive and Respiratory Syndrome Virus challenge. Scientific Reports. 6, 20305; doi: 10.1038/srep20305.
Novakovic, P., Al-Dissi, A. N., Harding, J. C. S., Ladinig, A., Detmer, S. E. 2016. Pathologic evaluation of type 2 PRRS virus infection at the maternal-fetal interface of pregnant gilts. PLoS ONE 11(3): e0151198. doi:10.1371/journal.pone.0151198
Ladinig, A., Ashley, C., Detmer, S. E., Lunney, J. K., Plastow, G., Harding, J. C. S. 2015. Maternal and fetal predictors of fetal viral load and death in porcine reproductive and respiratory syndrome virus infected pregnant gilts. Vet Res. 46(1): 107. PMID: 26407558
Ladinig, A., Detmer, S. E., Clarke, K., Ashley, C., Rowland, RRR., Lunney, J. K., Plastow, G., Harding, J. C. S. 2015. Pathogenicity of three type 2 Porcine Reproductive and Respiratory Syndrome virus strains in experimentally inoculated pregnant gilts. Virus Res. 203:24-35
Ladinig, A., Foxcroft, G., Ashley, C., Lunney, J. K., Plastow, G., Harding, J. C. S. 2014. Birth weight, intrauterine growth retardation and fetal susceptibility to porcine reproductive and respiratory syndrome virus. PLoS ONE. 9(10):e109541. doi:10.1371/journal.pone.0109541
Ladinig, A., Gerner, W., Saalmüller, A., Lunney, J. K., Ashley, C., Harding, J. C. S. 2014. Changes in leukocyte subsets of pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome. Vet Res. 45:128 (December 14, 2014)
Ladinig, A., Lunney, J. K., Souza, C. J. H., Ashley, C., Plastow, G., Harding, J. C. S. 2014. Cytokine profiles in pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome Vet Res. 45(1):113 (December 14, 2014) (Highly Accessed)
Ladinig, A., Wilkinson, J., Ashley, C., Detmer, S. E., Lunney, J. K., Plastow, G., Harding, J. C. S. 2014. Variation in fetal outcome, viral load and ORF5 sequence mutations in a large scale study of phenotypic responses to late gestation exposure to type 2 Porcine Reproductive and Respiratory Syndrome Virus. PLoS ONE 9(4): e0096104, DOI: 0.1371/journal.pone. April 22, 2014
Research theme: "Brachyspira hampsonii"
Johnson, L.A., Chaban, B., Harding, J.C.S., Hill, J.E. 2015. Optimizing a PCR protocol for cpn60-based microbiome profiling of samples variously contaminated with host genomic DNA. BMC Research Notes. 8:253. DOI: 10.1186/s13104-015-1170-4.
Costa, M. O., Chaban, B., Harding, J. C. S., Hill, J. E.. 2014. Changes the fecal microbiota of pigs following inoculation with ""Brachyspira hampsonii". PLoS ONE. 9(8): e106399. doi:10.1371/journal.pone.0106399
Costa, M. O., Hill, J. E., Fernando, C., Lemieux, H. D., Detmer, S. E., Rubin, J. E., Harding, J. C. S. 2014. Confirmation that "Brachyspira hampsonii" clade I (Canadian strain 30599) causes mucohemorrhagic diarrhea and colitis in experimentally infected pigs. BMC Vet Res. 10:128. Available at: www.biomedcentral.com/1746-6148/10/129
Rubin, J.E., Harms, N.J., Fernando, C., Soos, C., Detmer, S.E., Harding, J.C.S., Hill, J.E. 2013. Isolation and characterization of Brachyspira spp. including "Brachyspira hampsonii" from lesser snow geese (Chen caerulescens caerulescens) in the Canadian arctic. Microbial Ecology. 66:813-822.
Patterson, A. H., Rubin, J. E., Fernando C., Costa, M. O., Harding, J. C. S., Hill, J. E. 2013. Fecal shedding of Brachyspira spp. on a farrow-to-finish swine farm with a clinical history of “Brachyspira hampsonii”-associated colitis. BMC Veterinary Research. 9:137. DOI: 10.1186/1746-6148-9-137
Rubin, J. E., Costa, M. O., Hill, J. E., Kittrell, H., Fernando, C., Huang, Y., O'Connor, B., Harding, J. C. S. 2013. Reproduction of mucohaemorrhagic diarrhea and colitis indistinguishable from swine dysentery following experimental inoculation with “Brachyspira hampsonii” strain 30446. PLoS ONE. 8(2), e57146.doi 10.1371
Research theme: "Periweaning failure to thrive syndrome (PFTS)
Huang, Y., Harding, J. C. S. 2015. Editorial: Do genetics play a role in Porcine Periweaning Failure-to-Thrive Syndrome (PFTS)? Vet Rec. epub June 6, 2015. Pg 594 doi: 10.1136/vr.h2899.
Huang, Y., Harding, J.C.S. 2015. Pathological features and proposed diagnostic criteria of porcine peri-weaning failure-to-thrive syndrome. Vet Path. 52(3):489-496.
Huang, Y., Harding, J.C.S. 2014. Attempted experimental reproduction of porcine periweaning-failure-to-thrive syndrome using tissue homogenates. PLoS ONE 9(3): e90065. doi:10.1371/journal.pone
O’Sullivan, T. L., Harding, J., Friendship, R., Henry, S., Madson, D., Schwartz, K. 2013. Estimated prevalence and impact of periweaning failure-to-thrive syndrome in Canada and the United States of America. J. Swine Health Prod. 22(1):24-48.
Huang, Y., Gauvreau, H., Harding, J. 2012. Diagnostic investigation of Porcine Periweaning Failure to Thrive Syndrome (PFTS) in a farm. J Vet Diagn Invest. 24(1):96-106
Huang, Y., Henry, S., Friendship, R., Schwartz, K., Harding, J. 2011. Clinical presentation, case definition and diagnostic guidelines for Porcine “Periweaning Failure to Thrive Syndrome” (PFTS). J Swine Health Prod. 19(6):340-344
Research theme: Pre-natal programming, genomics, nursery health
Perri, A. M., Friendship, R. M., Harding, J. C. S., O’Sullivan, T. L. 2016. An investigation of iron deficiency and anemia in piglets and the effect of iron status at weaning on post-weaning performance. J Swine Health Prod. 24(1):10-19.
Harding, J. 2015. Genomics, animal models and emerging diseases: relevance to One Health and food security. Genome. 2015, 58(12): 499-502, 10.1139/gen-2015-0148.
Wilkinson, J. M., Gunvaldsen, R. E., Foxcroft, G. R., Dyck, M. K., Dixon, W. T., Plastow, G., Harding, J. C. S. 2015. Transcriptomic and epigenetic profiling of the lung of influenza-infected pigs: a comparison of different birth weight and susceptibility groups. ". PLoS ONE. 10(9): e0138653
Serão, N.V.L.; Matika, O.; Kemp, R. A.; Harding, J.C.S.; Bishop, S.C.; Plastow, G.S.; Dekkers, J.C.M. 2014. Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. J. Anim. Sci. 92:2905-2921. doi:10.2527/jas.2014-7821
Detmer, S. E., Gunvaldsen, R. E., Harding, J. C. 2013. Comparison of influenza A virus infection in high and low birth weight pigs using morphometric analysis. Influenza and Other Respiratory Viruses. 7 (Suppl. 4): 2-9. DOI:10.1111/irv.12199
SELECTED KEYNOTE PRESENTATIONS TO SWINE INDUSTRY (last 6 of 83 invited presentations)
Harding J. 2016. Emergence of "Brachyspira hampsonii" in western Canada: a collaborative success. Proc. 47th Annual Amer Assoc Swine vet Mtg., February 27-March 1, 2016. New Orleans, Louisiana.
Harding, J., 2015. Pathogenesis and diagnosis of "Brachyspira hampsonii " and Brachyspira hyodysenteriae. Australian Pig Veterinary Conference, Gold Coast, NSW, Australia. June 14-16, 2015.
Harding, J., Ladinig, A., Ashley, C., Lunney, J., Wilkinson, J., Detmer, S., Plastow, G. 2015. Genotypic and phenotypic predictors of reproductive PRRS severity. Australian Pig Veterinary Conference, Gold Coast, NSW, Australia. June 14-16, 2015.
Harding, J., Huang, Y., O'Sullivan, T. 2015. Anatomical and clinical pathology and pathogenesis of Periweaning Failure to Thrive Syndrome (PFTS). Australian Pig Veterinary Conference, Gold Coast, NSW, Australia. June 14-16, 2015.
Harding, J., 2014. Genomics, animal models and emerging diseases: relevance to "One Health" and food security. Genomics: the Power and the Promise. Genome Canada and the Gairdner Foundation. Ottawa, Canada. November 24-26, 2014.
Harding, J. C. S. 2014. Accountabilities in the age of transboundary and emerging porcine diseases. Proc. 23rd Int Pig Vet Soc Congr., Cancun, Mexico, June 8-11, 2014. Vol 1, Pg 1-14.
SELECTED RESEARCH FUNDING (last 5 of 39 total grants)
Dyck, M., Harding, J.C.S., Kemp, R. 2015. Application of Genomics to Improve Disease Resilience and Sustainability in Pork Production. Genome Canada, Genome Canada, Genome Alberta, Genome Prairie, Ontario Genetics Inc, and others (AWARDED: $9.8M of which $5.3M is new funding provided from the national and regional Genome Centres; $1.2M to support collaborators at the University of Saskatchewan; 4 yrs).
Loewen, M., Alexandersen, S., Pasick, J., Mote, B., Harding, J., Plastow, G. Detmer, S. 2014. Controlling Porcine Epidemic Diarrhea Virus (PEDV) by improving host resistance. Saskatchewan Agriculture and Development Fund. Project # 20140215 (AWARDED: $150,000 3 yr)
Harding, J., Alexandersen, S., Loewen, M., Pasick, J., Mote, B., Detmer, S. Rothschild, M., Plastow, G. 2014. Enhanced molecular diagnostics and validating genetic resistance to PEDV in pigs. Genome Alberta. Project number #PEDV 005. (AWARDED $250,250, 1.5 yr).
Plastow, G., Kemp, B., Bishop, S., Dekkers, J., Harding, J., Ford, C. 2014. Improving Canadian pork industry profits and export potential by developing genomic tools to enhance health, performance and disease resilience in wean to finish pigs. Alberta Livestock Genomics Program. Project # 024 (AWARDED $499, 500, 3 yr).
Hill, J. E., Harding, J. C. S., Hendrick, S., Waldner, C. 2014. Surveillance, diagnostics and control of emerging diseases of pigs and cattle: Towards control of novel pathogenic Brachyspira associated with mucohaemorrhagic colitis to enhance competitiveness and international trade of Canadian pork. Agriculture Innovation Program, AAFC. Project number #100083289. (AWARDED: $156,000 plus in kind of $37,500, 3 yrs)